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KMID : 0545120010110050895
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Journal of Microbiology and Biotechnology
2001 Volume.11 No. 5 p.895 ~ p.898
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Molecular Cloning and Characterization of the doxA Cytochrome P-450 Hydroxylase Gene in Streptomyces peucetius subsp. caesius ATCC 27952
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HONG, YOUNG-SOO
KIM, HANG SUB/LEE, JEONG-HYUNG/KIM, KYU-WON/LEE, JUNG JOON
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Abstract
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DNA sequence analysis of doxA from Streptomyces peucetius subsp. caesius ATCC 27952 revealed a 95% amino acid identity with that of Streptomyces strain C5. DoxA from S. peucetius subsp. caesius ATCC 27952 encodes a peptide with both conserved heme-binding and dioxygen-binding motifs. Expression of this gene in S. lividans 1326 resulted in bioconversion of daunorubicin to doxorubicin.
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